The African continent today is emblematic of tuberculosis (TB) as a global health emergency with little known about the long-term sequelae. There is cumulative evidence for prolonged pulmonary morbidity and loss of longevity in former TB patients. It is likely that TB patients from resource-constrained settings, who usually present with more extensive disease, are left with substantial and chronic lung impairment.

This project aims:

to advance the understanding of the clinical, microbiologic, environmental and host immune factors affecting the long-term sequelae of pulmonary TB;

to determine occurrence of reversible and irreversible costs and socioeconomic consequences for TB patients and health care systems;

and to facilitate novel interventions to restore and preserve overall health, well-being and financial protection in patients with TB.

The project is organized into 3 work packages: