The TB Sequel Network is a research consortium which was built on pre-existing long standing research collaborations. All partners of the Network are highly regarded for their expertise in tuberculosis clinical research, including diagnostics, biomarkers, drug evaluation, immunology, conventional and molecular epidemiology, and socio-economic impact and are successfully collaborating for more than 15 years. The TB Sequel Project is an integral part of an overall strategy to fill a knowledge gap needed to move forward to a more comprehensive concept and understanding of TB cure and long-term impact of TB.